venofer dosing calculatorvenofer dosing calculator

2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Use Caution/Monitor. Avoid or Use Alternate Drug. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. Applies only to oral form of both agents. 4. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Below the form there are further instructions on how to use the calculator. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Either increases effects of the other by pharmacodynamic synergism. 1000 mg. 20 MINUTES. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Applies only to oral form of both agents. Applies only to oral form of both agents. Avoid or Use Alternate Drug. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. 5. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. https://www.uptodate.com/ (Requires subscription). Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. The elemental iron product used is Iron sucrose 20 mg/mL. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Use Caution/Monitor. Observed Hb = the patients current hemoglobin in g/dl. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? iron sucrose, benazepril. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Avoid or Use Alternate Drug. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. May increase risk of hypotension. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Use alternatives if available. Applies only to oral form of both agents. Venofer has not been studied in patients younger than 2 years old. It can be expressed in mg per ml. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Applies only to oral form of both agents. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). For liquid medications, also enter the value of the Medicine Concentration and choose . Fill in the calculator/tool with your values and/or your answer choices and press Calculate. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) FERAHEME met the predefined criteria for non-inferiority to Venofer . During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Applies only to oral form of both agents. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Although the original formula requires the weight in kilograms, values input in lbs are transformed. Applies only to oral form of both agents. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. Applies only to oral form of both agents. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. restrictions. Applies only to oral form of both agents. Contraindicated. Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Each mL contains 20 mg of elemental iron. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Use Caution/Monitor. Applies only to oral form of both agents. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Treatment of anemia due to iron deficiency. Applies only to oral form of both agents. 3. Applies only to oral form of both agents. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Most sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. No additional iron to replenish stores. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Use Caution/Monitor. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. This drug is available at a higher level co-pay. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Avoid or Use Alternate Drug. Nutr Clin Pract. Use Caution/Monitor. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Applies only to oral form of both agents. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. US residents can call their local poison control center at 1-800-222-1222. Either decreases levels of the other by inhibition of GI absorption. commonly, these are generic drugs. LBW = Lean body weight in kg. Corrected Calcium. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). We'll do this entirely for free, as long as the calculator has applications for women's health. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Compare formulary status to other drugs in the same class. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Last updated 28/06/2018 Enter values here and press 'Calculate'. Share cases and questions with Physicians on Medscape consult. . Copyright 2021 GlobalRPH - Web Development by. Mean change in Hgb from baseline to Week 5 2,5 May increase risk of hypotension. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW Applies only to oral form of both agents. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Contraindicated. Administer a test INFeD dose prior to the first therapeutic dose. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Deferoxamine chelates iron. A healthcare provider will give you this injection. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Minor/Significance Unknown. Reference www.medicines.org.uk Background Administer Venofer early during the dialysis session (generally within the first hour). Use Caution/Monitor. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Applies only to oral form of both agents. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Minor/Significance Unknown. Drug Des Devel Ther; 5: 5160. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. You can further save the PDF or print it. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Human studies not conducted. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. David McAuley, Pharm.D. Avoid or Use Alternate Drug. prescription products. Separate by 2 hr. https://www.uptodate.com/ (Requires subscription). omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. If you log out, you will be required to enter your username and password the next time you visit. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Applies only to oral form of both agents. If either is present, do not use the liquid. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Always ask your health care professional for complete information about this product and your specific health needs. (See also Notes section. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Use Caution/Monitor. Am J Hosp Pharm. You will have to pay for your IV iron. 1988 May;111(5):566-70. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Anemias. Avoid or Use Alternate Drug. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Use Caution/Monitor. 1996 Aug;11(4):139-46. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. No data are available regarding overdosage of Venofer in humans. Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Applies only to oral form of both agents. 1998 Feb;25(1):65-8. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. Separate dosing of tetracyclines from these products. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. This document does not contain all possible drug interactions. 1 ,*. Separate dosing of tetracyclines from these products. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Minor/Significance Unknown. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. Modify Therapy/Monitor Closely. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Iron sucrose: 20 mg/mL. Either increases effects of the other by pharmacodynamic synergism. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Applies only to oral form of both agents. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 1. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. Applies only to oral form of both agents. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Ferric gluconate: 12.5 mg/mL. The dosage of iron sucrose is expressed in mg of elemental iron. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. . Separate by at least 4 hours. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). 1) Ganzoni AM. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Applies only to oral form of both agents. Use Caution/Monitor. commonly, these are "non-preferred" brand drugs or specialty 1974 Jun;31(6):592-5. Individual plans may vary Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Venofer [package insert]. Each mL contains 20 mg of elemental iron. Minor/Significance Unknown. Do not administer Venofer to patients with evidence of iron overload. A: Generally acceptable. Venofer must only be administered intravenously either by slow injection or by infusion. Each mL contains 20 mg of elemental iron. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. 1970;100(7):301303. Burns DL, Mascioli EA, Bistrian BR. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Anemia; 2015: 763576. Use Caution/Monitor. Methods. 1 Dosing for patients who weigh less than 50 kg The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. J Med. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Medicinal forms Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. This drug is available at the lowest co-pay. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Where: Medicine concentration Amount of active substance per a given volume of your drug. . Modify Therapy/Monitor Closely. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Treatment of anemia due to iron deficiency. Use Caution/Monitor. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Kumpf VJ. Recommended dosing and infusion rates for PI. By clicking send, you acknowledge that you have permission to email the recipient with this information. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). 2.1 . Applies only to oral form of both agents. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Applies only to oral form of both agents. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Applies only to oral form of both agents. Applies only to oral form of both agents. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 Use Caution/Monitor. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Anemia; 2015: 763576. . Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. and formulary information changes. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. 1. Schweiz Med Wochenschr. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). ONE DOSE. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Use Caution/Monitor. Creating an account is free and takes less than 1 minute. Please confirm that you would like to log out of Medscape. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. Minor/Significance Unknown. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Applies only to oral form of both agents. Access your plan list on any device mobile or desktop. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Minor/Significance Unknown. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. trientine, iron sucrose. Use Caution/Monitor. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days.

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