inappropriate sinus tachycardia and covid vaccineinappropriate sinus tachycardia and covid vaccine

Chest 157, A453 (2020). Heart Fail. 40, 3139 (2019). J. Biomol. Postgrad. Commun. Autonomic dysfunction is relatively common among HIV-infected patients, as inferred from a decrease in the HRV in the early stages of infection in many of these patients13. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. The National Institute on Minority Health and Health Disparities at the National Institutes of Health has identified investigation of short- and long-term effects of COVID-19 on health, and how differential outcomes can be reduced among racial and ethnic groups, as a research priority216. Chowkwanyun, M. & Reed, A. L. Racial health disparities and COVID-19caution and context. Heart Rhythm S15475271(20), 3114131143. Clin. Selected Adverse Events Reported after COVID-19 Vaccination Thank you for visiting nature.com. J. Cugno, M. et al. 17, 10401046 (2020). Inappropriate Sinus Tachycardia Follow Posted 6 years ago, 9 users are following. Dyn. J. World Neurosurg. Things that may lead to tachycardia include: Fever Heavy alcohol use or alcohol withdrawal High levels of caffeine High or low blood pressure Nephrol. Postural Orthostatic Tachycardia Syndrome: Possibly Covid Vaccine Therapeutic anticoagulation for those with imaging-confirmed VTE is recommended for 3months, similar to provoked VTE72,111. Acta Neuropathol. J. We present a case of a 15-year-old South Asian male who developed suspected POTS two weeks after receiving the Pfizer-BioNTech COVID-19 vaccine booster, which was successfully managed with low-dose Recovered patients may have persistently increased cardiometabolic demand, as observed in long-term evaluation of SARS survivors118. Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort. 131, 19311932 (2020). Hosey, M. M. & Needham, D. M. Survivorship after COVID-19 ICU stay. Now Katalin Kariko, 66, known to colleagues as Kati, has emerged as one of the heroes of Covid-19 vaccine development. The findings from studies reporting outcomes in subacute/ongoing symptomatic COVID-19 and chronic/post-COVID-19 syndrome are summarized in Table 1. Cheung, K. S. et al. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics. Care Med. Malnutrition has been noted in 2645% of patients with COVID-19, as evaluated by the Malnutrition Universal Screening Tool in an Italian study219. Tachycardia Syndrome May Be a Distinct Marker for Long COVID - Medscape Wrobel, A. G. et al. We found that IST is prevalent among PCS patients (affecting 20% in our series), and this disorder was more common in young women without previous comorbidities and with mild SARS-CoV-2 infection. Incidence of venous thromboembolism in hospitalized patients with COVID-19. Respir. Ritchie, K., Chan, D. & Watermeyer, T. The cognitive consequences of the COVID-19 epidemic: collateral damage? 5). Kidney Int. Demographic data were summarized by basic descriptive statistics in the three groups. S.M. The predominant dermatologic complaint was hair loss, which was noted in approximately 20% of patients5,26. Parauda, S. C. et al. Meier, P., Bonfils, R. M., Vogt, B., Burnand, B. A review of potential options for therapeutic intervention. Huang, C. et al. In COVID-19, Faecalibacterium prausnitzii, a butyrate-producing anaerobe typically associated with good health, has been inversely correlated with disease severity196,199. A.S.N. & Sullivan, R. M. Inappropriate sinus tachycardia. 16, 565567 (2020). The IST subjects had a mean heart rate of 1052bpm supine and 12511bpm in the upright position. Postolache, T. T., Benros, M. E. & Brenner, L. A. Targetable biological mechanisms implicated in emergent psychiatric conditions associated with SARS-CoV-2 infection. Sci. Stress and psychological distress among SARS survivors 1 year after the outbreak. Model COVID-19 rehabilitation units such as those in Italy are already routinely assessing acute COVID-19 survivors for swallowing function, nutritional status and measures of functional independence219. Dr.Kerryn Phelps is the former President of the Australian Medical Association (AMA). Ongoing investigations may provide insight into potential immune or inflammatory mechanisms of disease202. A comprehensive understanding of patient care needs beyond the acute phase will help in the development of infrastructure for COVID-19 clinics that will be equipped to provide integrated multispecialty care in the outpatient setting. 13, 1722 (2006). Peleg, Y. et al. IST occurred in the absence of fever and was persistent in nearly 40% of patients during 3weeks of follow-up. Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase. Su, H. et al. Clin. Histopathologic and ultrastructural findings in postmortem kidney biopsy material in 12 patients with AKI and COVID-19. Finally, our results suggest a major role of the ANS in the pathophysiology of IST. Madjid, M. et al. Gupta, S. et al. reports a consultant or advisory role for Abbott Vascular, Bristol-Myers Squibb, Portola and Takeda, as well as research support (institutional) from CSL Behring. No report of Inappropriate sinus tachycardia is found in people who take L reuteri. 'I apologize on behalf of my profession for refusing to listen to patients with vax injuries' - Dr. Michael Huang, physician who treated 4,000 COVID patients says he's seen hundreds of COVID-19 vaccine injuries, cancer, pregnancy loss, etc.. Dr. Melissa Halvorson Smith MD. Arany, J., Bazan, V., Llads, G. et al. Lung transplantation in pulmonary fibrosis secondary to influenza A pneumonia. HR indicates heart rate; PNN50, percentage of adjacent NN intervals that differ from each other by more than 50 ms; SD, standard deviation of the interbeat interval; VLF, very low frequency; LF, low frequency; HF, high frequency. Am. Usually, women and people assigned female at birth in their 30s tend to get this type of . Am. Chest 158, 11431163 (2020). COVID-19 Vaccine Injured Doctors are Finally Starting to Speak Up Chest pain. Moreno-Prez, O. et al. Continuous variables were tested for normal distribution using QQ plots. Rehabil. 2. PubMedGoogle Scholar. Autonomic nervous system dysfunction: JACC focus seminar. To investigate the prevalence and the mechanisms underlying IST in a prospective population of PCS patients. Am. Assoc. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. Cardiac autonomic nervous system imbalance with decreased parasympathetic activity may explain this phenomenon. Analysis of lung tissue from five cases with severe COVID-19-associated pneumonia, including two autopsy specimens and three specimens from explanted lungs of recipients of lung transplantation, showed histopathologic and single-cell RNA expression patterns similar to end-stage pulmonary fibrosis without persistent SARS-CoV-2 infection, suggesting that some individuals develop accelerated lung fibrosis after resolution of the active infection62. Immun. J. Thromb. Tenforde, M. W. et al. Curr. 63(8), 793801. Kociol, R. D. et al. Thorax 60, 401409 (2005). High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy. HAN Archive - 00442 | Health Alert Network (HAN) - Centers for Disease In a prospective cohort study from Wuhan, China, long-term consequences of acute COVID-19 were evaluated by comprehensive in-person evaluation of 1,733 patients at 6months from symptom onset (hereby referred to as the post-acute COVID-19 Chinese study)5. Williamson, E. J. et al. Physical activity and ambulation should be recommended to all patients when appropriate102. This may explain the disproportionately high rates (2030%) of thrombotic rather than bleeding complications in acute COVID-19 (ref. Lancet Infect. Eur. Article Wu, Y. et al. Haemost. 74, 860863 (2020). In this regard, we conducted a systematic review to investigate and characterize the clinical settings of these reported cases to aid in physician awareness and proper care provision. Sinus tachycardia is the most common arrhythmia in Covid-19 patients. Soc. PubMed Based on recent literature, it is further divided into two categories: (1) subacute or ongoing symptomatic COVID-19, which includes symptoms and abnormalities present from 412weeks beyond acute COVID-19; and (2) chronic or post-COVID-19 syndrome, which includes symptoms and abnormalities persisting or present beyond 12weeks of the onset of acute COVID-19 and not attributable to alternative diagnoses17,19. Ann. Of 488 patients who completed the telephone survey in this study, 32.6% of patients reported persistent symptoms, including 18.9% with new or worsened symptoms. For this reason, we performed the same tests in two gender- and age-controlled groups, one with matched disease stage and severity and one without previous infection. PubMed The burden of supraventricular premature beats was lower in IST-PCS patients. Therapeutic anticoagulation with enoxaparin or warfarin and low-dose aspirin is recommended in those with a coronary artery zscore10, documented thrombosis or an ejection fraction<35%. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Finally, long-term cognitive impairment is well recognized in the post-critical illness setting, occurring in 2040% of patients discharged from an ICU165. Serial electrocardiograms and consideration of an ambulatory cardiac monitor are recommended at follow-up visits in patients with conduction abnormalities at diagnosis. Dis. https://doi.org/10.1016/j.wneu.2020.05.193 (2020). Mazza, M. G. et al. 21, 163 (2020). PubMed Surg. Higher nasal epithelial expression of TMPRSS2 has been reported in Black individuals compared with other self-reported races/ethnicities217. 41(10), 26572669. Based on recent literature, it is further divided into two categories: (1) subacute or ongoing symptomatic COVID-19, which includes symptoms and abnormalities present from 4-12 weeks beyond acute. Eur. Inappropriate sinus tachycardia (IST) occurs when the heart beats very quickly without a good reason. 324, 13811383 (2020). 163, 345354 (2003). Ann. 'I apologize on behalf of my profession for refusing to listen to patients with vax injuries' - Dr. Michael Huang, physician who treated 4000 COVID patients says he's seen hundreds of COVID-19 vaccine injuries, cancer, pregnancy loss, etc. Inappropriate sinus tachycardia (IST) is a common observation in patients with post-COVID-19 syndrome (PCS) but has not yet been fully described to date. Subacute thyroiditis after SARS-COV-2 infection. https://doi.org/10.1016/j.hrthm.2020.12.007 (2020). 20, 11351140 (2020). 20, 697706 (2020). Res. JAMA Otolaryngol. Similar to chronic post-SARS syndrome, COVID-19 survivors have reported a post-viral syndrome of chronic malaise, diffuse myalgia, depressive symptoms and non-restorative sleep133,134. Goldberger, J. J. et al. Childs Nerv. Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection. Inappropriate sinus tachycardia If you have sinus tachycardia with no known cause, it's called inappropriate sinus tachycardia (IST). Med. Curr. Localisation of transforming growth factor 1 and 3 mRNA transcripts in normal and fibrotic human lung. Kaseda, E. T. & Levine, A. J. Post-traumatic stress disorder: a differential diagnostic consideration for COVID-19 survivors. J. Thromb. Immunol. Faecalibacterium prausnitzii and human intestinal health. Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation. Emerg. 31, 19591968 (2020). Med. The authors declare no competing interests. Article Med. https://doi.org/10.7326/M20-6306 (2020). 3). Opin. 1. In adults, a heart rate greater than 100 beats per minute when a person is at rest is considered tachycardia. Posterior reversible encephalopathy syndrome in patients with COVID-19. In rare cases, the COVID-19 vaccine can cause a severe allergic reaction, which is why people should be monitored after the injection. Swai, J., Hu, Z., Zhao, X., Rugambwa, T. & Ming, G. Heart rate and heart rate variability comparison between postural orthostatic tachycardia syndrome versus healthy participants; A systematic review and meta-analysis. Libby, P. & Lscher, T. COVID-19 is, in the end, an endothelial disease. Moreover, SARS-CoV-1 and SARS-CoV-2 share the same host cell receptor: ACE2. https://doi.org/10.1001/jama.2020.12603 (2020). Rev. Clinical and immunological features of severe and moderate coronavirus disease 2019. https://doi.org/10.1001/jamaneurol.2020.2065 (2020). PubMed Central An observational cohort study from 38 hospitals in Michigan, United States evaluated the outcomes of 1,250 patients discharged alive at 60d by utilizing medical record abstraction and telephone surveys (hereby referred to as the post-acute COVID-19 US study)20. Med. 161), with a more sustained increase in severe infections162, suggesting the possibility of more chronic neuronal injury. All statistical analyses were performed using SPSS version 25.0 (IBM, Armonk, NY, USA). Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. BMC Neurol. 19, 141154 (2021). Patients with IST had a higher mean heart rate, predominantly during the daytime, compared to recovered asymptomatic and uninfected subjects (986 vs. 848 vs. 816bpm, respectively; p<0.001). 73(10), 11891206. 98, 509512 (2020). J. Med. Neurologia 35, 318322 (2020). & Sun, Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. However, the pharmacological agent of choice, the timing of its administration, and the clinical response will warrant a separate investigation. 77(8), 10181027. In a cohort of 402 COVID-19 survivors in Italy 1month after hospitalization, approximately 56% screened positive in at least one of the domains evaluated for psychiatric sequelae (PTSD, depression, anxiety, insomnia and obsessive compulsive symptomatology)143. Blood 136, 13301341 (2020). Survivors of previous coronavirus infections, including the SARS epidemic of 2003 and the Middle East respiratory syndrome (MERS) outbreak of 2012, have demonstrated a similar constellation of persistent symptoms, reinforcing concern for clinically significant sequelae of COVID-19 (refs. Open Forum Infect. 26, 10171032 (2020). Shah, W., Hillman, T., Playford, E. D. & Hishmeh, L. Managing the long term effects of COVID-19: summary of NICE, SIGN, and RCGP rapid guideline. In most people, these symptoms come and go so . Thorax 75, 10091016 (2020). Infect. Med. Overall, biochemistry data were consistent with a lack of inflammation or myocardial damage at this stage after the acute phase of SARS-CoV-2 infection. J. 94(1), 16. Schaller, T. et al. Correspondence to J. Cardiol. J. Med. These important differences noted in preliminary studies may be related to multiple factors, including (but not limited to) socioeconomic determinants and racial/ethnic disparities, plausible differences in the expression of factors involved in SARS-CoV-2 pathogenesis, and comorbidities. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb. Potential pitfalls and practical guidance. 194, 145158 (2014). At physical examination, the mean heart rate was 96 3bpm at supine and 112 17bpm at the upright position, with 8 patients fulfilling diagnostic criteria of POTS. Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study. ISSN 2045-2322 (online). Rey, J. R. et al. Post-acute COVID-19 is defined as persistent symptoms and/or delayed or long-term complications beyond 4weeks from the onset of symptoms. Retrospective data on post-acute thromboembolic events, although limited by small sample size, variability in outcome ascertainment and inadequate systematic follow-up, suggest the rate of venous thromboembolism (VTE) in the post-acute COVID-19 setting to be <5%. Pharmacological agents targeting thromboinflammation in COVID-19: review and implications for future research. 21(1), e63e67. More common side effects are mild and temporary, including: fever. All post-acute COVID-19 follow-up studies that incorporated assessments of health-related quality of life and functional capacity measures have universally reported significant deficits in these domains, including at 6months in the post-acute COVID-19 Chinese study3,5,20. J. Neurol. A report of three cases. Kidney Int. . Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 3: hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and other cardiomyopathies, and myocarditis: a scientific statement from the American Heart Association and American College of Cardiology. Caccialanza, R. et al. Inappropriate Sinus Tachycardia | Cedars-Sinai The baseline characteristics of the 40 IST cases and their matched controls are presented in Table 1. In our initial experience with PCS patients, IST, which often overlaps with POTS, is also a common observation that has not been fully described to date. Clin. Hui, D. S. et al. Crit. Vaduganathan, M. et al. 26, 681687 (2020). the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in PubMed Central 22, 25072508 (2020). & McIntyre, R. S. The involvement of TNF- in cognitive dysfunction associated with major depressive disorder: an opportunity for domain specific treatments. Am. The virus that causes COVID-19 is designated "severe acute . J. Clin. J. PubMed Central Association of neuronal injury blood marker neurofilament light chain with mild-to-moderate COVID-19. So far, there is no evidence that COVID-19-associated diabetes can be reversed after the acute phase, nor that its outcomes differ in COVID-19 long haulers. Google Scholar. https://doi.org/10.7326/M20-5661 (2020). Google Scholar. The study utilized survey questionnaires, physical examination, 6-min walk tests (6MWT) and blood tests and, in selected cases, pulmonary function tests (PFTs), high-resolution computed tomography of the chest and ultrasonography to evaluate post-acute COVID-19 end organ injury. Am. Clin. JAMA Cardiol. Such groups include COVID Advocacy Exchange (https://www.covidadvocacyexchange.com), the National Patient Advocate Foundation COVID Care Resource Center (https://www.patientadvocate.org/covidcare), long-haul COVID fighters Facebook groups, the Body Politic COVID-19 Support Group (https://www.wearebodypolitic.com/covid19), Survivor Corps (https://www.survivorcorps.com/) and Patient-Led Research for COVID-19 (patientresearchcovid19.com). Brugliera, L. et al. Hair loss can possibly be attributed to telogen effluvium resulting from viral infection or a resultant stress response5. Connors, J. M. & Levy, J. H. COVID-19 and its implications for thrombosis and anticoagulation. 16, 581589 (2020). & Jenkins, R. G. Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy. Desai, A. D., Boursiquot, B. C., Melki, L. & Wan, E. Y. is chair of the scientific advisory board for Applied Therapeutics, which licenses Columbia University technology unrelated to COVID-19 or COVID-19-related therapies. Assoc. 'Inappropriate' Sinus Tachycardia - medscape.com Neuropsychol. All these medications can change the potassium currents in the heart, which can cause prolongation of the QT interval. HRCT, high-resolution computed tomography; PE, pulmonary embolism. Secondary causes of tachycardia, such as anemia, thyroid pathology, pregnancy, infection, or pulmonary embolism, were investigated, and patients with a systemic condition justifying tachycardia were excluded from the study analysis. 2(3), ofv103. and R.V. However, autopsy series have shown that SARS-CoV-2 may cause changes in brain parenchyma and vessels, possibly by effects on bloodbrain and bloodcerebrospinal fluid barriers, which drive inflammation in neurons, supportive cells and brain vasculature155,156. Miglis, M. G., Goodman, B. P., Chmali, K. R. & Stiles, L. Re: Post-COVID-19 chronic symptoms by Davido et al. N. Engl. Med. https://doi.org/10.1212/wnl.43.1_part_1.132 (1993). Among 200 PCS patients, 40 (20%) fulfilled the diagnostic criteria for IST (average age of 40.110years, 85% women, 83% mild COVID-19). However, this is not the first time that IST has been described after coronavirus infection. Rep. 5, 940945 (2020). 29, 200287 (2020). J. Freeman, E. E. et al. In the post-acute COVID-19 Chinese study, the median 6-min walking distance was lower than normal reference values in approximately one-quarter of patients at 6months5a prevalence similar to that in SARS and MERS survivors9. J. Infect. Forty-four patients with a resting heart rate 100bpm were initially screened, 4 of whom were excluded due to mean 24-h heart rate <90bpm (n=2), hyperthyroidism (n=1), or severe mitral regurgitation (n=1). No patient was under any cardiovascular treatment at the time of the evaluation. Wang, Q. et al. Thachil, J. Hypoxiaan overlooked trigger for thrombosis in COVID-19 and other critically ill patients. Accordingly, the loss of HRV is suggestive of a cardiac ANS imbalance with decreased parasympathetic activity and compensatory sympathetic activation. He referred the patient to CV who reviewed the patient with JSO, diagnosed postural orthostatic tachycardia syndrome and advised commencement of ivabradine. Salvio, G. et al. 31, 21582167 (2020). Roberts, L. N. et al. Biomarkers of cerebral injury, such as elevated peripheral blood levels of neurofilament light chain, have been found in patients with COVID-19 (ref. The need for supplemental oxygen due to persistent hypoxemia, or new requirement for continuous positive airway pressure or other breathing support while sleeping, was reported in 6.6 and 6.9% of patients, respectively, at 60d follow-up in the post-acute COVID-19 US study20. Puchner, B. et al. A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations. 3(2), e000700. McCrindle, B. W. et al. Pavoni, V. et al. Sharma, P. et al. Van Kampen, J. J. Med. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Nephrol. Moores, L. K. et al. Get the most important science stories of the day, free in your inbox. Brain Behav. Lancet Infect. Open 3, e2014780 (2020). 2, 12001203 (2020). If associated with the COVID-19 vaccine, cases of TTS/VITT occurred several days up to 2-1/2 weeks after being vaccinated with the Johnson & Johnson (Janssen) COVID-19 vaccine in the U.S., or up . Circulation 120, 725734 (2009). 43, 401410 (2015). Soc. "Professor Shmuel Shapira might be the most senior ranking medical-scientist in the world to openly criticize the COVID vaccines." On May 13, 2022, Dr. Shapira said: "I received 3 vaccinations (Pfizer), I was physically injured in a very significant way as many others were injured". Lazzerini, P. E., Laghi-Pasini, F., Boutjdir, M. & Capecchi, P. L. Cardioimmunology of arrhythmias: the role of autoimmune and inflammatory cardiac channelopathies. Prioritization of follow-up care may be considered for those at high risk for post-acute COVID-19, including those who had severe illness during acute COVID-19 and/or required care in an ICU, those most susceptible to complications (for example, the elderly, those with multiple organ comorbidities, those post-transplant and those with an active cancer history) and those with the highest burden of persistent symptoms. Isolated Tachycardia Presenting After Pfizer-BioNTech COVID-19 - Cureus Inappropriate Sinus Tachycardia | Saint Luke's Health System 1). Silent hypoxia in COVID-19: Pathomechanism and possible management strategy. COVID-19 rapid guideline: managing the long-term effects of COVID-19. Blood 136, 13471350 (2020). Anaphylaxis after COVID-19 vaccination is rare and has occurred at a rate of approximately 5 cases per one million vaccine doses administered. Am. Background: Since the advent of global COVID-19 vaccination, several studies reported cases of encephalitis with its various subtypes following COVID-19 vaccinations. 218(3), e20202135. Brit. There are several therapies being used to treat the virus infection known as COVID-19, including the medications Chloroquine, Hydroxychloroquine and Azithromycin. Cardiac ANS imbalance with decreased parasympathetic activity seems to be a plausible pathophysiological explanation for this phenomenon. This case report is clinically relevant to better understand the pathophysiology behind the messenger RNA (mRNA) coronavirus disease 2019 (COVID-19) vaccine and the . Post-discharge venous thromboembolism following hospital admission with COVID-19. Ameres, M. et al. In some people, massaging the carotid sinus in the neck will stop the problem. The subsequent inflammatory response may lead to cardiomyocyte death and fibro-fatty displacement of desmosomal proteins important for cell-to-cell adherence116,117. Extrapulmonary manifestations of COVID-19. https://doi.org/10.1016/j.amjmed.2020.12.009 (2021). 324, 22512252 (2020). 99, 470474 (2020). Gupta, A. et al. J. Clin. In our study, most of the patients could not be evaluated for silent hypoxemia because arterial blood gases were not performed during the acute phase. J. Thromb. Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Coker, R. K. et al. https://doi.org/10.1038/s41591-021-01283-z. Diabetes Obes. Characterization of the inflammatory response to severe COVID-19 Illness. Post-intensive care syndrome: its pathophysiology, prevention, and future directions. Am. Luks, A. M. & Swenson, E. R. Pulse oximetry for monitoring patients with COVID-19 at home. Am. J. Crit. COVID-19-induced postural orthostatic tachycardia syndrome treated with

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